Laparoscopic Cholecystectomy Update 2006 Reasons for Exclusion
| Study | Reasons for exclusion |
| 1. Acil 2004 | Pain scores not presented |
| 2. Agarwal 2003 | No VAS pain assessment |
| 3. Agarwal 2004 | Propofol-induced pain not postop-pain |
| 4. Agnifili 1993 | Compares lap chole against open procedure |
| 5. Akca 2004 | Combined lap chole and groin hernia repair groups |
| 6. Argiriadou 2002 | No VAS pain assessment |
| 7. Assalia 1993 | No VAS pain assessment + open cholecystectomy |
| 8. Assalia 1997 | No VAS pain assessment + open cholecystectomy |
| 9. Awad 2002 | No VAS pain assessment |
| 10. Barkun 1992 | Compares lap chole against mini-lap chole procedure |
| 11. Barkun 1993 | Duplicates data in Barkun 1992 |
| 12. Berberoglu 1998 | No VAS pain assessment |
| 13. Berggren 1994 | No VAS pain assessment |
| 14. Berven 1995 | RCT – status unclear + no VAS pain assessment |
| 15. Bhoyrul 2000 | Combined procedures |
| 16. Bisgaard 2002 | Not a comparative study |
| 17. Biswas 2003 | No VAS pain assessment |
| 18. Boldt 1998 | Not RCT |
| 19. Brackman 2002 | No VAS pain assessment + cost savings study |
| 20. Buanes 1993 | Not RCT |
| 21. Buanes 1996 | Not RCT |
| 22. Byrne 1994 | Compares lap chole against open procedure |
| 23. Campbell 2000 | No VAS pain assessment |
| 24. Camus 1995 | No VAS pain assessment |
| 25. Cason 1996 | Not RCT |
| 26. Cete 1996 | Conventional cholecystectomy |
| 27. Chan 1994 | Not RCT |
| 28. Chan 1995 | Not RCT |
| 29. Chen 1995 | Not RCT |
| 30. Chok 2004 | Not RCT |
| 31. Chow 1997 | Retrospective |
| 32. Colak 2004 | Compares use vs. re-use of disposable instruments |
| 33. Collier 1993 | Not RCT |
| 34. Cox 1992 | Retrospective |
| 35. Croce 1999 | Not laparoscopic cholecystectomy (duodenal ulcers) |
| 36. Cunniffe 1998 | Mixed laparoscopic procedures |
| 37. Dahl 1994 | Minilaparotomy cholecystectomy |
| 38. Davides 1999 | Not RCT |
| 39. Dill 2000 | Not RCT |
| 40. Eberhart 1999a | No VAS pain assessment |
| 41. Eberhart 1999b | Compares antiemetics not analgesics |
| 42. Ehsan-ul-Haq 2004 | No pain assessment |
| 43. Eldar 1997 | Not RCT |
| 44. Ell 1990 | Piezoelectric lithotripsy |
| 45. Fiorillo 1996 | Not RCT |
| 46. Frank 1990 | Conventional cholecystectomy |
| 47. Frenette 1991 | Conventional cholecystectomy |
| 48. Fujii 2000 | No pain assessment |
| 49. Fujii 2004 | No pain assessment; nausea and vomiting study |
| 50. Gan 2004b | Used Joshi 2004 data, but tested hypothesis that reducing opioid consumption reduced opioid-related side effects |
| 51. Gharaibeh 2000 | No VAS pain assessment |
| 52. Gillberg 1993 | Gynaecological laparoscopy |
| 53. Golder 1998 | No VAS pain assessment specified. Comparison of operative techniques |
| 54. Gurmarnik 1996 | No VAS pain assessment |
| 55. Habib 2004 | No VAS pain assessment |
| 56. Hakanson 1989 | Conventional cholecystectomy |
| 57. Hanaoka 2004 | No VAS pain assessment |
| 58. Hasaniya 2001 | No VAS pain assessment |
| 59. Helmy 1999 | No VAS pain assessment |
| 60. Hendolin 2000 | Compares lap chole against open procedure |
| 61. Hong 2003b | Physiological study, no pain assessment |
| 62. Hong 2003a | Gynaecological laparoscopy |
| 63. Horattas 2004 | No VAS pain assessment |
| 64. Hsieh 2003 | Acute cholecystitis, no VAS assessment |
| 65. Huang 1990 | Conventional cholecystectomy |
| 66. Inan 2004 | Not RCT |
| 67. Jallali 2004 | No VAS pain assessment + not relevant (investigating closure techniques) |
| 68. Jelicic 1993 | Conventional cholecystectomy |
| 69. Jensen 2002 | Laparotomy |
| 70. Jensen 2004 | Used Joshi 2004 data, but investigated the relationship between several predictors and patient satisfaction |
| 71. Johansson 2005 | Compares lap chole vs. open procedure |
| 72. Joris 1992 | Not RCT |
| 73. Joris 1998 | Gastroplasty |
| 74. Karayiannakis 1997 | Compares lap chole vs. open procedure |
| 75. Kenady 1992 | Conventional cholecystectomy |
| 76. Khan 1997 | No VAS pain assessment |
| 77. Khan 2002 | No VAS pain assessment |
| 78. Kimberley 1996 | Not RCT |
| 79. Kitano 1993 | No VAS pain assessment |
| 80. Klockgether-Radke 1996 | No VAS pain assessment |
| 81. Koivuranta 1996 | No VAS pain assessment |
| 82. Koivusalo 1996 | No VAS pain assessment |
| 83. Koivusalo 1997 | No VAS pain assessment |
| 84. Koivusalo 2000 | Review paper |
| 85. Kolla 2004 | Statistical analysis of pain outcomes unclear |
| 86. Kristiansson 1999 | Not RCT |
| 87. Kum 1994 | Not RCT |
| 88. Lai 1998 | No VAS pain assessment |
| 89. Larsen 2002 | Only abstract in English |
| 90. Laurito 1991 | Conventional cholecystectomy |
| 91. Le Blanc-Louvry 2000 | Compares lap chole vs. open procedure |
| 92. Lee 1990 | Conventional cholecystectomy |
| 93. Lee 2005 | Not RCT |
| 94. Lindgren 1997 | No VAS pain assessment |
| 95. Los 1995 | No VAS pain assessment |
| 96. Lysak 1994 | Gynaecological laparoscopy |
| 97. Madsen 1992 | Not RCT |
| 98. Maidatsi 1998 | Conventional cholecystectomy |
| 99. Majeed 1996 | No VAS pain assessment |
| 100. McCrory 2002 | Review paper |
| 101. McGinn 1995 | No VAS pain assessment |
| 102. McLaughlin 1994 | Gynaecological laparoscopy |
| 103. McMahon 1994a | Compares lap chole vs. mini-lap chole |
| 104. McMahon 1994b | Compares lap chole vs. mini-lap chole |
| 105. Mealy 1992 | Not RCT |
| 106. Morino 1998 | No VAS pain assessment + Study about hepatic function |
| 107. Mrsic 1997 | RCT-status unclear |
| 108. Murrell 1996 | Not just lap chole |
| 109. Naguib 1996 | Compares antiemetics not analgesics |
| 110. Naude 1996 | No VAS pain assessment + Study about hormone changes |
111. Nesek-Adam 2004 |
Compares antiemetics not analgesics |
112. O’Boyle 2002 |
Combined procedures Study cited before June 2002, included in initial analysis |
| 113. O’Dwyer 1992 | No VAS pain assessment |
| 114. Ortega 1995 | Appendectomy |
| 115. Ortega 1996 | Compares lap chole vs. open procedure |
| 116. Oxorn 1989 | Conventional cholecystectomy |
| 117. Ozkocak 2002 | Only abstract in English |
| 118. Paolucci 1995 | No VAS pain assessment |
| 119. Paventi 2001 | Compares antiemetics not analgesics |
| 120. Perry 1993 | Gynaecological laparoscopy |
| 121. Power 1990 | Conventional cholecystectomy |
| 122. Quaynor 2002 | No VAS pain assessment |
| 123. Rademaker 1991 | Conventional cholecystectomy |
| 124. Raeder 1998 | VAS pain scores not recorded |
| 125. Roberts-Thomson 1994 | Conventional cholecystectomy |
| 126. Ros 2004 | No VAS pain assessment |
| 127. Rosenblum 1991 | Gynaecological laparoscopy |
| 128. Ross 1989 | Conventional cholecystectomy |
| 129. Sarli 2001 | Combined procedures |
| 130. Sarli 2001 | Not RCT |
| 131. Schmitz 1997 | Conventional cholecystectomy vs. minicholecystectomy |
| 132. Schroeder 1990 | Conventional cholecystectomy |
| 133. Schulze 1988 | Conventional cholecystectomy |
| 134. Schwenk 2002 | Not a comparison of treatment modalities |
| 135. Scott 1989 | Conventional cholecystectomy |
| 136. Shah 1986 | Conventional cholecystectomy |
| 137. Smith 1993 | Procedures other than laparoscopic cholecystectomy |
| 138. Smythe 1993 | No VAS pain assessment. Unclear if any patients received laparoscopic cholecystectomy |
| 139. So 2002 | Compares antiemetics not analgesics |
| 140. Song 2000 | No VAS pain assessment |
| 141. Squirrell 1998 | Comparison of operative procedures not pain relief after laparoscopic cholecystectomy |
| 142. Steffen 1997 | Only abstract in English |
| 143. Steinbrook 1998 | Compares antiemetics not analgesics |
| 144. Sternlo 1992 | Conventional cholecystectomy |
| 145. Striebel 1993 | Conventional cholecystectomy |
| 146. Stromskag 1991 | Conventional cholecystectomy |
| 147. Tarnow 1998 | Conventional cholecystectomy |
| 148. Taylor 1992 | No pain assessment included |
| 149. Trondsen 1993 | Compares lap chole vs. open procedure |
| 150. Ure 1994 | Not RCT |
| 151. Uzunkoy 1999 | Duplicates Uzunkoy 2001 |
| 152. Van Delden 2002 | No VAS pain assessment + Dose-response study |
| 153. van Raay 1992 | Conventional cholecystectomy |
| 154. Varrassi 1994 | Conventional cholecystectomy |
| 155. Verborgh 1994 | Conventional cholecystectomy |
| 156. Vetrhus 2004 | Combined laparoscopic + open cholecystectomy |
| 157. Vetrhus 2004 | No VAS pain assessment + not relevant (risk assessment study) |
| 158. Vieira 2004 | Only abstract in English |
| 159. Wajima 1998 | Conventional cholecystectomy |
| 160. Wallin 1988 | Conventional cholecystectomy |
| 161. Wang 2002 | Nausea and vomiting study comparing anti-emetic regimens |
| 162. Wani 2000 | Conventional cholecystectomy vs. minicholecystectomy |
| 163. Weinbroum 2001 | No sub-analysis of laparoscopic cholecystectomy patients |
| 164. Westerling 1997 | Minilaparotomy |
| 165. Witjes 1992 | Conventional cholecystectomy |
| 166. Yang 2004 | No VAS pain assessment |
| 167. Yotsui 2001 | Not double-blinded. No pain assessment |
| 168. Yu 2003 | No VAS pain assessment |
| 169. Zhao 2004 | Health outcomes analysis of Joshi 2004 data |